The present manuscript describe simple, sensitive, rapid, accurate, precise and economical first derivative spectrophotometric method for the simultaneous determination of Rosuvastatin calcium and telmisartan in combined tablet dosage form. The derivative spectrophotometric method was based on the determination of both the drugs at their respective zero crossing point (ZCP). The first order derivative spectra was obtained in methanol and the determinations were made at 248nm (ZCP of telmisartan) for rosuvastatin calcium and 296.7nm (ZCP of rosuvastatin calcium) for telmisartan. The linearity was obtained in the concentration range of 2-18μg/ml for rosuvastatin calcium and 1-6 μg/ml for telmisartan. The mean recovery was 99.85± 0.27and 99.73 ± 0.44 for rosuvastatin calcium and telmisartan, respectively. The method was found to be simple, sensitive, accurate and precise and was applicable for the simultaneous determination of rosuvastatin calcium and telmisartan in pharmaceutical tablet dosage form. The results of analysis have been validated statistically and by recovery studies.
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